Genetic causes of breast cancer

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translati...

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Cellular signaling pathways are not isolated from each other but are intercoected to form complex signaling networks. Cells receive information from many different growth factor receptors and from cell-matrix and cell-cell contacts. They must then inte- grate this information to regulate diverse processes, such as protein synthesis and cell growth, motility, cell architecture and polarity, differentiation, and programmed cell death. The same signaling molecules are used to control different processes within different signaling complexes or at different intracellular locations. Moreover, signaling pathways are subject to develop- mental regulation and generate different outcomes in different ...